Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures

English version

Autoři: Soo Ching Lee ^aff001; Mei San Tang ^aff003; Alice V. Easton ^aff003; Joseph Cooper Devlin ^aff003; Ling Ling Chua ^aff004; Ilseung Cho ^aff006; Foong Ming Moy ^aff007; Tsung Fei Khang ^aff008; Yvonne A. L. Lim ^aff001; P’ng Loke ^aff003
Působiště autorů: Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ^aff001; Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia ^aff002; Department of Microbiology, New York University School of Medicine, New York, New York, United States of America ^aff003; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia ^aff004; Department of Paediatrics, Faculty of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia ^aff005; Department of Medicine, Division of Gastroenterology, New York University School of Medicine, New York, New York, United States of America ^aff006; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ^aff007; University of Malaya Centre for Data Analytics, University of Malaya, Kuala Lumpur, Malaysia ^aff008; Institute of Mathematical Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia ^aff009
Vyšlo v časopise: Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures. PLoS Pathog 15(12): e32767. doi:10.1371/journal.ppat.1008066
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.ppat.1008066

Souhrn

Helminth infection and dietary intake can affect the intestinal microbiota, as well as the immune system. Here we analyzed the relationship between fecal microbiota and blood profiles of indigenous Malaysians, referred to locally as Orang Asli, in comparison to urban participants from the capital city of Malaysia, Kuala Lumpur. We found that helminth infections had a larger effect on gut microbial composition than did dietary intake or blood profiles. Trichuris trichiura infection intensity also had the strongest association with blood transcriptional profiles. By characterizing paired longitudinal samples collected before and after deworming treatment, we determined that changes in serum zinc and iron levels among the Orang Asli were driven by changes in helminth infection status, independent of dietary metal intake. Serum zinc and iron levels were associated with changes in the abundance of several microbial taxa. Hence, there is considerable interplay between helminths, micronutrients and the microbiota on the regulation of immune responses in humans.

Klíčová slova:

Blood – Gene regulation – Gut bacteria – Helminth infections – Helminths – Microbiome – principal component analysis – Zinc

Zdroje

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