Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys

English version

Autoři: Quintin Lee ^aff001; Matthew P. Padula ^aff002; Natalia Pinello ^aff001; Simon H. Williams ^aff003; Matthew B. O'Rourke ^aff004; Marcílio Jorge Fumagalli ^aff005; Joseph D. Orkin ^aff006; Renhua Song ^aff001; Babak Shaban ^aff008; Ori Brenner ^aff009; John E. Pimanda ^aff010; Wolfgang Weninger ^aff001; William Marciel de Souza ^aff005; Amanda D. Melin ^aff006; Justin J.-L. Wong ^aff001; Marcus J. Crim ^aff013; Sébastien Monette ^aff014; Ben Roediger ^aff001; Christopher J. Jolly ^aff010
Působiště autorů: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia ^aff001; Proteomics Core Facility, University of Technology Sydney, Sydney, NSW, Australia ^aff002; Center for Infection & Immunity, Mailman School of Public Health, Columbia University, New York, NY, United States of America ^aff003; Kolling Institute of Medical Research, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia ^aff004; Virology Research Center, School of Medicine of Ribeirão Preto of the University of São Paulo, Ribeirão Preto, Brazil ^aff005; Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, Barcelona, Spain ^aff006; Department of Anthropology and Archaeology, University of Calgary, Alberta, Canada ^aff007; Melbourne Integrative Genomics, University of Melbourne, Melbourne, Victoria, Australia ^aff008; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel ^aff009; Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia ^aff010; Department of Dermatology, Medical University of Vienna, Vienna, Austria ^aff011; Department of Medical Genetics and Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada ^aff012; Microbiology and Aquatic Diagnostics, IDEXX BioAnalytics, Discovery Drive, Columbia, MO, United States of America ^aff013; Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, United States of America ^aff014; Autoimmunity, Transplantation, Inflammation (ATI) Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland ^aff015
Vyšlo v časopise: Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. PLoS Pathog 16(1): e32767. doi:10.1371/journal.ppat.1008262
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.ppat.1008262

Souhrn

Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify “p10” and “p15” as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.

Klíčová slova:

Bird genomics – Gene prediction – Introns – Kidneys – Mammalian genomics – Parvoviruses – Polymerase chain reaction – Polyadenylation

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