#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience


Autoři: Maria C. Perez-Matos aff001;  William B. Mair aff001
Působiště autorů: Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America aff001
Vyšlo v časopise: Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience. PLoS Genet 16(7): e32767. doi:10.1371/journal.pgen.1008833
Kategorie: Perspective
doi: https://doi.org/10.1371/journal.pgen.1008833


Zdroje

1. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, et al. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 Jun 14;23(6):1093–112. doi: 10.1016/j.cmet.2016.05.027 27304509

2. Wilkie SE, Mulvey L, Sands WA, Marcu DE, Carter RN, Morton NM, et al. Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice. Geroscience [Internet]. 2020 Mar 11; Available from: http://dx.doi.org/10.1007/s11357-020-00168-2

3. Liao C-Y, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010 Feb;9(1):92–5. doi: 10.1111/j.1474-9726.2009.00533.x 19878144

4. Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell. 2013;12(6):1050–61. doi: 10.1111/acel.12130 23837470

5. Aw WC, Towarnicki SG, Melvin RG, Youngson NA, Garvin MR, Hu Y, et al. Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness. PLoS Genet. 2018 Nov;14(11):e1007735. doi: 10.1371/journal.pgen.1007735 30399141

6. Zhu C-T, Ingelmo P, Rand DM. G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity. PLoS Genet. 2014 May 15;10(5):e1004354. doi: 10.1371/journal.pgen.1004354 24832080

7. Gao AW, Sterken MG, Uit de Bos J, van Creij J, Kamble R, Snoek BL, et al. Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels. Genome Res. 2018 Sep;28(9):1296–308. doi: 10.1101/gr.232322.117 30108180

8. Stanley PD, Ng’oma E, O’Day S, King EG. Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in a Drosophila Multiparent Population. Genetics. 2017 Jun;206(2):587–602. doi: 10.1534/genetics.116.197780 28592498

9. Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, et al. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metab. 2019 Sep 3;30(3):573–93.e8. doi: 10.1016/j.cmet.2019.06.018 31353263

10. Nelson CS, Beck JN, Wilson KA, Pilcher ER, Kapahi P, Brem RB. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. BMC Genomics. 2016 Nov 4;17(1):867. doi: 10.1186/s12864-016-3137-9 27809764

11. Jin K, Wilson KA, Beck JN, Nelson CS, Brownridge GW III, Harrison B, et al. Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila. PLoS Genet. 2020 Jul;16(7):e1008835

12. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19;510(7505):397–401 doi: 10.1038/nature13264 24828042


Článek vyšel v časopise

PLOS Genetics


2020 Číslo 7
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autoři: MUDr. Tomáš Ürge, PhD.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Závislosti moderní doby – digitální závislosti a hypnotika
Autoři: MUDr. Vladimír Kmoch

Aktuální možnosti diagnostiky a léčby AML a MDS nízkého rizika
Autoři: MUDr. Natália Podstavková

Jak diagnostikovat a efektivně léčit CHOPN v roce 2024
Autoři: doc. MUDr. Vladimír Koblížek, Ph.D.

Všechny kurzy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#