Origins of DNA replication

English version

Autoři: Babatunde Ekundayo ^aff001; Franziska Bleichert ^aff001
Působiště autorů: Quantitative Biology, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland ^aff001
Vyšlo v časopise: Origins of DNA replication. PLoS Genet 15(9): e1008320. doi:10.1371/journal.pgen.1008320
Kategorie: Topic Page
doi: https://doi.org/10.1371/journal.pgen.1008320

Souhrn

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes. DNA synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. Here, we discuss commonalities and differences in replication origin organization and recognition in the three domains of life.

Klíčová slova:

Biology and life sciences – Genetics – DNA – DNA replication – DNA structure – Biochemistry – Nucleic acids – Enzymology – Enzymes – Helicases – Proteins – DNA-binding proteins – Organisms – Eukaryota – Fungi – Yeast – Saccharomyces – Saccharomyces cerevisiae – Cell biology – Cell processes – Cell cycle and cell division – Molecular biology – Macromolecular structure analysis – Research and analysis methods – Animal studies – Experimental organism systems – Model organisms – Yeast and fungal models

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