Distinct genetic variation and heterogeneity of the Iranian population

English version

Autoři: Zohreh Mehrjoo ^aff001; Zohreh Fattahi ^aff001; Maryam Beheshtian ^aff001; Marzieh Mohseni ^aff001; Hossein Poustchi ^aff002; Fariba Ardalani ^aff001; Khadijeh Jalalvand ^aff001; Sanaz Arzhangi ^aff001; Zahra Mohammadi ^aff002; Shahrouz Khoshbakht ^aff001; Farid Najafi ^aff003; Pooneh Nikuei ^aff004; Mohammad Haddadi ^aff005; Elham Zohrehvand ^aff001; Morteza Oladnabi ^aff006; Akbar Mohammadzadeh ^aff001; Mandana Hadi Jafari ^aff001; Tara Akhtarkhavari ^aff001; Ehsan Shamsi Gooshki ^aff008; Aliakbar Haghdoost ^aff010; Reza Najafipour ^aff012; Lisa-Marie Niestroj ^aff013; Barbara Helwing ^aff014; Yasmina Gossmann ^aff015; Mohammad Reza Toliat ^aff013; Reza Malekzadeh ^aff002; Peter Nürnberg ^aff013; Kimia Kahrizi ^aff001; Hossein Najmabadi ^aff001; Michael Nothnagel ^aff013
Působiště autorů: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran ^aff001; Digestive Disease Research Centre, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran ^aff002; Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran ^aff003; Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran ^aff004; Department of Biology, University of Zabol, Zabol, Iran ^aff005; Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran ^aff006; Department of Medical Genetics, Faculty of Advanced Medical Technologies, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran ^aff007; Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran ^aff008; Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran ^aff009; Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran ^aff010; Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran ^aff011; Cellular and Molecular Research Centre, Genetic Department, Qazvin University of Medical Sciences, Qazvin, Iran ^aff012; Cologne Center for Genomics, University of Cologne, Cologne, Germany ^aff013; Department of Archaeology, The University of Sydney, Australia ^aff014; Noncommunicable Disease Research Center, Shiraz University of Medical Science, Shiraz, Iran ^aff015; University Hospital Cologne, Cologne, Germany ^aff016
Vyšlo v časopise: Distinct genetic variation and heterogeneity of the Iranian population. PLoS Genet 15(9): e32767. doi:10.1371/journal.pgen.1008385
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1008385

Souhrn

Iran, despite its size, geographic location and past cultural influence, has largely been a blind spot for human population genetic studies. With only sparse genetic information on the Iranian population available, we pursued its genome-wide and geographic characterization based on 1021 samples from eleven ethnic groups. We show that Iranians, while close to neighboring populations, present distinct genetic variation consistent with long-standing genetic continuity, harbor high heterogeneity and different levels of consanguinity, fall apart into a cluster of similar groups and several admixed ones and have experienced numerous language adoption events in the past. Our findings render Iran an important source for human genetic variation in Western and Central Asia, will guide adequate study sampling and assist the interpretation of putative disease-implicated genetic variation. Given Iran’s internal genetic heterogeneity, future studies will have to consider ethnic affiliations and possible admixture.

Klíčová slova:

Arabic people – Asia – Language – Population genetics – Iran – Paleogenetics – Persian people – Ancient DNA

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