Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

Authors: Connor A. Emdin; Mary E. Haas; Amit V. Khera; Krishna Aragam; Mark Chaffin; Derek Klarin; George Hindy; Lan Jiang; Wei-Qi Wei; Qiping Feng; Juha Karjalainen; Aki Havulinna; Tuomo Kiiskinen; Alexander Bick; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Danish Saleheen; Kyong-Mi Chang; Marijana Vujkovic; Ben Voight; Scott Damrauer; Julie Lynch; David Kaplan; Marina Serper; Philip Tsao; Million Veteran Program; Josep Mercader; Craig Hanis; Mark Daly; Joshua Denny; Stacey Gabriel; Sekar Kathiresan
Published in the journal: Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genet 17(4): e1009503. doi:10.1371/journal.pgen.1009503
Category: Correction
doi: https://doi.org/10.1371/journal.pgen.1009503

In this article, the genetic variant PNPLA3 p.I148M is misreported in several sentences as PNPLA3 p.I48M. The variant TM6SF2 p.E167K is misreported in one sentence as TM6SF2 p.E40K.

In the Introduction, the third sentence of the second paragraph:

For example, PNPLA3 p.I48M and TM6SF2 p.E40K, although initially identified as associated with hepatic steatosis [9,10], strongly predispose to the development of alcoholic cirrhosis [11], non-alcoholic cirrhosis [12,13] and hepatitis C-related cirrhosis [14,15].

should read:

For example, PNPLA3 p.I1148M and TM6SF2 p.E167K, although initially identified as associated with hepatic steatosis [9,10], strongly predispose to the development of alcoholic cirrhosis [11], non-alcoholic cirrhosis [12,13] and hepatitis C-related cirrhosis [14,15].

In the Results, the fourth sentence of the first paragraph:

We examined the association of all-cause cirrhosis with six genetic variants previously reported to be associated with alcoholic or non-alcoholic cirrhosis: PNPLA3 I48M, TM6SF2 E167K, MBOAT7 rs641738, HSD17B13 rs72613567, HFE C282Y and SERPINA1 E366K [11,16,18,19].

should read:

We examined the association of all-cause cirrhosis with six genetic variants previously reported to be associated with alcoholic or non-alcoholic cirrhosis: PNPLA3 I148M, TM6SF2 E167K, MBOAT7 rs641738, HSD17B13 rs72613567, HFE C282Y and SERPINA1 E366K [11,16,18,19].

In the Methods, the first sentence of the first paragraph:

To examine whether known alcoholic and non-alcoholic cirrhosis variants associate with all-cause cirrhosis, we tested the association of six known cirrhosis variants (PNPLA3 I48M, TM6SF2 E167K, MBOAT7 rs641738, HSD17B13 rs72613567, HFE C282Y and SERPINA1 E366K [11,16,18,19]) with all-cause cirrhosis in UK Biobank (hospitalization or death due to ICD codes K70.2, K70.3, K70.4, K74.0, K74.1, K74.2, K74.6, K76.6, or I85).

should read:

To examine whether known alcoholic and non-alcoholic cirrhosis variants associate with all-cause cirrhosis, we tested the association of six known cirrhosis variants (PNPLA3 I148M, TM6SF2 E167K, MBOAT7 rs641738, HSD17B13 rs72613567, HFE C282Y and SERPINA1 E366K [11,16,18,19]) with all-cause cirrhosis in UK Biobank (hospitalization or death due to ICD codes K70.2, K70.3, K70.4, K74.0, K74.1, K74.2, K74.6, K76.6, or I85).

There is an error in Table 1. The name p.I48M appears instead of p.I148M.

**Tab. 1. DNA sequence variants associated with all-cause cirrhosis in the discovery analysis.**

There is an error in the label of S1 Fig. The name p.I48M appears instead of p.I148M. The authors have provided a corrected version here.

Supporting information

S1 Fig [pdf]
Risk of alcoholic, non-alcoholic and hepatitis C cirrhosis associated with PNPLA3 I148M, TM6SF2 E167K and HSD17B13.

Zdroje

1. Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, et al. (2020) A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genet 16(4): e1008629. https://doi.org/10.1371/journal.pgen.1008629 32282858

Článek Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies

Článek Functional assessment of the “two-hit” model for neurodevelopmental defects in Drosophila and X. laevis

Článek ARID1A regulates R-loop associated DNA replication stress

Článek Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior

Článek Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis

Článek Virus-derived variation in diverse human genomes

Článek Aurora kinase A is essential for meiosis in mouse oocytes

Článek Pathways and signatures of mutagenesis at targeted DNA nicks

Článek LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNA

Článek A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots

Článek Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes

Článek PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease