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Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis


Autoři: Alfredo Rago aff001;  John H. Werren aff002;  John K. Colbourne aff001
Působiště autorů: School of Biosciences, The University of Birmingham, Birmingham, United Kingdom aff001;  Department of Biology, University of Rochester, Rochester, NY, United States of America aff002
Vyšlo v časopise: Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis. PLoS Genet 16(1): e32767. doi:10.1371/journal.pgen.1008518
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1008518

Souhrn

Sexual dimorphism requires regulation of gene expression in developing organisms. These developmental differences are caused by differential expression of genes and isoforms. The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). However, few studies have described how these processes change across development. We compare the dynamics of differential expression, isoform switching and functional interactions in the sexual development of the model parasitoid wasp Nasonia vitripennis, a system that permits genome wide analysis of sex bias from early embryos to adults. We find relatively little sex-bias in embryos and larvae at the gene level, but several sub-networks show sex-biased functional interactions in early developmental stages. These networks provide new candidates for hymenopteran sex determination, including histone modification. In contrast, sex-bias in pupae and adults is driven by the differential expression of genes. We observe sex-biased isoform switching consistently across development, but mostly in genes that are already differentially expressed. Finally, we discover that sex-biased networks are enriched by genes specific to the Nasonia clade, and that those genes possess the topological properties of key regulators. These findings suggest that regulators in sex-biased networks evolve more rapidly than regulators of other developmental networks.

Klíčová slova:

DNA transcription – Embryos – Gene expression – Gene regulation – Genetic networks – Gonads – Invertebrate genomics – Sexual differentiation


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