Ureasa a její vztah k ureolytickým bakteriím a hledání nových inhibitorů ureasy

English version

Autoři: Petra Hřibová; Elian Khazneh
Působiště autorů: University of Veterinary and Pharmaceutical Sciences Brno
Vyšlo v časopise: Čes. slov. Farm., 2014; 63, 248-252
Kategorie: Přehledy a odborná sdělení

Souhrn

Vnásledujícím souhrnu je uveden přehled dostupné literatury na aktuální téma týkající se enzymu ureasy. Ureasa je enzym katalyzující hydrolýzu močoviny. Vpřehledu je diskutován výskyt ureasy, její funkce avýznam arovněž role ureasy aureolytických bakterií vpatogenezi různých onemocnění. Jsou prezentovány známé anorganické ipřírodní inhibitory ureasy. Práce se zabývá důležitostí hledání nových inhibitorů ureasy apotenciálem přírodních látek vtéto oblasti.

Klíčová slova:
bakterie • inhibitor • ureasa

Zdroje

1. Mobley H. L., Island M. D., Hausinger R. P. Molecular biology of microbial ureases. Microbiol. Rev. 1995; 59, 451–480.

2. Krajewska B. Ureases I. Funcional, catalytic and kinetic properties: A review. J. Mol. Catal. B: Enzym. 2009; 59, 9–21.

3. Upadhyay L. S. B. Urease inhibitors: A review. Indian J. Biotechnol. 2012; 11, 381–388.

4. Thomas B., Tolley D. Concurrent urinary tract infection and stone disease: pathogenesis, diagnosis and management. Nat. Clin. Pract. Urol. 2008; 5, 668–675.

5. Ghous T., Akhtar K., Nasim F. H., Choudhry M. A. Screening of selected medicinal plants for urease inhibitory activity. Biol. Med. 2010; 2, 64–69.

6. Burne R. A., Chen Y. M. Bacterial ureases in infectious diseases. Microbes Infect. 2000; 2, 533−542.

7. Balasubramanian A., Ponnuraj K. Crystal structure of the first plant urease from jack bean: 83 years of journey from its first crystal to molecular structure. J. Mol. Biol. 2010; 400, 274–283.

8. Carlsson H., Nordlander E. Computational modeling of the mechanism of urease. Bioinorg. Chem. Appl. 2010; 2010, 1–8.

9. Benini S., Rypniewski W. R., Wilson K. S., Miletti S., Ciurli S., Mangani S. A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels. Structure. 1999; 7, 205–216.

10. Mobley H. L., Hausinger, R. P. Microbial ureases: significance, regulation and molecular characterization. Microbiol. Revi. 1989; 53, 85–103.

11. Krajewska B. Ureases. II. Properties and their customizing by enzyme immobilizations: A review. J. Mol. Catal. B: Enzym. 2009; 59, 22–40.

12. Odake S., Morikawa T., Tsuchiya M., Imamura L., Kobashi K. Inhibition of Helicobacter pylori urease activity by hydroxamic acid derivatives. Biol. Pharm. Bull. 1994; 17, 1329–1332.

13. Stingl K., De Reuse H. Staying alive overdosed: How does Helicobacter pylori control urease activity? Int. J. Med. Microbiol. 2005; 295, 307–315.

14. Pounder R. E., Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment. Pharm. Therap. 1995; 9 (Suppl. 2), 33–39.

15. Sachs G., Scott D. R. Helicobacter pylori: Eradication or Preservation. F1000 Med. Rep. 2012; 4.

16. Broutet N., Marais A., Lamouliatte H., de Mascarel A., Samoyeau R., Salamon R., Megraud F. cagA Status and Eradication Treatment Outcome of Anti– Helicobacter pylori Triple Therapies in Patients with Nonulcer Dyspepsia. J. Clin. Microbiol. 2001; 39, 1319–1322.

17. Tonkic A., Tonkic M., Lehours P., Megraud F. Epidemiology and diagnosis of Helicobacter pylori infection. Helicobacter. 2012; 17(Suppl 1), 1–8.

18. Cutler A. F., Havstad S., Ma C. K., Blaser M. J., Perez-Perez G. I., Schubert T. T. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology. 1995; 109, 136–141.

19. Elfant A. B., Howden C. W., Stollman N. Contemporary diagnostic strategies for the detection of Helicobacter pylori infection. Gastroenterol. Hepatol. 2012; 8(Suppl 7), 0512P–5839.

20. Hall P. Nephrolithiasis: Treatment, causes, and prevention. Clev. Clin. J. Med. 2013; 76, 583–591.

21. Votava M. Lékařská mikrobiologie speciální. Brno: Neptun, 2003.

22. Myers J. A., Gill V. M., Cunha B. A. Corynebacterium urealyticum Urinary Tract Infections. Antimicrob. Infect. Dis. Newsl. 1995; 14, 83–84.

23. Varel V. H. Livestock manure odor abatement with plant-derived oils and nitrogen conservation with urease inhibitors: A review. J. Anim. Sci. 2002; 80 (E-Suppl 2), E1–E7.

24. Uesato S., Hashimoto Y., Nishino M., Nagaoka Y., Kuwajima H. N-substituted hydroxyureas as urease inhibitors. Chem. Pharm. Bull. 2002; 50, 1280–1282.

25. Berlicki Ł., Bochno M., Grabowiecka A., Białas A., Kosikowska P., Kafarski P. N-substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases. Amino acids. 2012; 42, 1937–1945.

26. Paun G., Litescu S. C., Neagu E., Tache A., Lucian Radu G. Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and αα-chymotrypsin. J. Enzym. Inhib. Med. Ch. 2013; 0, 1–7.

27. Shabana S., Kawai A., Kai K., Akiyama K., Hayashi H. Inhibitory activity against urease of quercetin glycosides isolated from Allium cepa and Psidium guajava. Biosci. Biotech. Bioch. 2010; 74, 878–880.

28. Matsubara S., Shibata H., Ishikawa F., Yokokura T., Takahashi M., Sugimura T., Wakabayashi K. Suppression of Helicobacter pylori–induced gastritis by green tea extract in Mongolian gerbils. Biochem. Bioph. Res. Co. 2003; 310, 715–719.

29. Ahmad I., Fatima I., Afza N., Malik A., Lodhi M. A., Choudhary M. I. Urease and serine protease inhibitory alkaloids from Isatis tinctoria. J. Enzym. Inh. Med. Ch. 2008; 23, 918–921.

30. Paulo L., Oleastro M., Gallardo E., Queiroz J. A., Domingues F. Anti-Helicobacter pylori and urease inhibitory activities of resveratrol and red wine. Food Res. Int. 2011; 44, 964–969.

31. Arfan M., Ali M., Ahmad H., Anis I., Khan A., Choudhary M. I., Shah M. R. Urease inhibitors from Hypericum oblongifolium WALL. J. Enzym. Inh. Med. Ch. 2010; 25, 296–299.

32. Kot M., Karcz W., Zaborska W. 5-Hydroxy-1,4-naphthoquinone (juglone) and 2-hydroxy-1,4-naphthoquinone (lawsone) influence on jack bean urease activity: Elucidation of the difference in inhibition activity. Bioorg. Chem. 2010; 38, 132–137.

33. Juszkiewicz A., Zaborska A., Łaptaś A., Olech Z. A study of the inhibition of jack bean urease by garlic extract. Food Chem. 2004; 85, 553–558.

34. Khan W. N., Lodhi M. A., Ali I., Azhar-Ul-Haq, Malik A., Bilal S., Gul R., Choudhary M. I. New natural urease inhibitors from Ranunculus repens. J. Enzym. Inhib. Med. Ch. 2006; 21, 17–19.

35. Ahmad V. U., Hussain J., Hussain H., Jassbi A. R., Ullah F., Lodhi M. A., Yasin A., Choudhary M. I. First natural urease inhibitor from Euphorbia decipiens. Chem. Pharm. Bull. 2003; 51, 719–723.

36. Zaborska W., Krajewska B., Kot M., Karcz W. Quinone-induced inhibition of urease: Elucidation of its mechanisms by probing thiol groups of the enzyme. Bioorg. Chem. 2007; 35, 233–242.

37. Xiao Z. P., Shi D. H., Li H. Q., Zhang L. N., Xu C., Zhu H. L. Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease. Bioorgan. Med. Chem. 2007; 15, 3703–3710.

38. Wong W., DeLuca C. I., Tian B., Wilson I., Molund S., Warriar N., Govindan M. V., Segal D., Chao H. Urease-induced alkalinization of extracellular pH and Its antitumor activity in human breast and lung cancers. J. Exp. Ther. Oncol. 2005; 5, 93–99.