Nanočásticové systémy uvolňující léčivo při změně teploty

English version

Autoři: Miloslava Rabišková; Eva Koziolová; Johana Jirásková
Působiště autorů: Faculty of Pharmacy, Charles University in Prague ; Department of Pharmaceutical Technology
Vyšlo v časopise: Čes. slov. Farm., 2014; 63, 239-247
Kategorie: Přehledy a odborná sdělení

Souhrn

Lékové transportní systémy reagující na vnější podněty jsou schopné uvolnit léčivou látku požadovaným řízeným způsobem v závislosti na spouštěcím mechanismu. Spouštěcí mechanismus může být fyzikální, chemické nebo biologické povahy. Termoresponzivní lékové transportní systémy odpovídají na změnu teploty a byly navrženy zejména k léčbě rakoviny metodou využívající působení zvýšené teploty, tj. hypertermii. Termoresponzivní systémy lze rozdělit do několika skupin, např. termoresponzivní hydrogelové polymerní systémy, lipozomy, nano- nebo mikročástice a polypeptidové konjugáty s léčivem. Zatímco lipozomy jsou citlivé na zvýšení teploty již svým složením, ostatní systémy jsou obvykle založené na termosenzitivních polymerech, zejména poly-(N-izopropyl-akrylamidu). Tento článek shrnuje poslední dostupné informace týkající se cíleného uvolňování léčiv v závislosti na změně teploty.

Klíčová slova:
lékový transportní systém • termoresponzivní systém • poly-(N-izopropyl-akrylamid) • lipozom • nanočástice • peptidový konjugát s léčivem

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