Vliv extraktu Aronia melanocarpa na složení fosfolipidů myokardu potkana během stresu

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Autoři: Volodymyr Shvets; Hanna Maslak; Vadim Davydov; Halyna Berest; Inna Nosulenko
Vyšlo v časopise: Čes. slov. Farm., 2022; 71, 98-102
Kategorie: Původní práce
doi: https://doi.org/https://doi.org/10.5817/CSF2022-3-98

Souhrn

Výzkum byl proveden na 80 samcích potkanů linie Wistar. Byla použita zvířata dvou věkových skupin: dospělí (10–12 měsíců) a staří (22–25 měsíců). Získaná data ukazují, že rozvoj imobilizačního stresu u dospělých a starých potkanů je doprovázen tvorbou charakteristického komplexu změn ve fosfolipidovém složení myokardu. Intraperitoneální injekce extraktu z temnoplodce černoplodého (Aronia melanocarpa) v dávce 0,2 g/kg 60 minut před imobilizací má omezenou modulaci stresu složení fosfolipidů myokardu u starých zvířat. Extrakt z Aronia melanocarpa tak zvyšuje odolnost myokardu vůči negativnímu účinku stresu.

Klíčová slova:

stárnutí – myokard – imobilizace – Aronia melanocarpa

Zdroje

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