Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study
Authors:
Brant M. Wagener; Parker J. Hu; Joo-Yeun Oh; Cilina A. Evans; Jillian R. Richter; Jaideep Honavar; Angela P. Brandon; Judy Creighton; Shannon W. Stephens; Charity Morgan; Randal O. Dull; Marisa B. Marques; Jeffrey D. Kerby; Jean-Francois Pittet; Rakesh P. Patel
Published in the journal:
Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study. PLoS Med 16(11): e32767. doi:10.1371/journal.pmed.1002991
Category:
Correction
doi:
https://doi.org/10.1371/journal.pmed.1002991
There is an error in Panel B of Fig 6 and the associated caption. The authors have provided a corrected Fig 6 and caption here.
In the Results, in the subsection “Heme levels in patients after TH and resuscitation”, there is an error in the fifth sentence of the first paragraph. The correct sentence is: Fig 6B plots the ratio of Hp/2:hemoglobin and Hpx:free heme. The ratio of Hp/2:hemoglobin was greater than 1 (median = 3.5, IQR 1.1–6.0, p<0.01 by one sample t-test and comparison to a theoretical mean of one), although variance is noted. For hemopexin:free heme, this ratio was lower (median = 0.56, IQR 0.34–0.86) and below one (p<0.01 by one sample t-test and comparison to a theoretical mean of one).
In the Discussion, there is an error in the seventh sentence of the eighth paragraph. The correct sentence is: While the absolute concentration of these mediators is important, the relative concentrations of hemoglobin and free heme, compared to Hp and Hpx respectively is likely of greater clinical significance; Hp and Hpx are the endogenous primary defense mechanisms protecting against hemolysis-dependent injury. We show that Hp levels were higher than Hpx, with the Hp:hemoglobin dimer ratio being greater than 1.
There is an error in the tab “Fig 6A–6B” of the S1 Data file. The authors have provided a corrected S1 Data file here.
Supporting information
S1 Data [xlsx]
Raw data presented in Figs 1–6.
Zdroje
1. Wagener BM, Hu PJ, Oh J-Y, Evans CA, Richter JR, Honavar J, et al. (2018) Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study. PLoS Med 15(3): e1002522. https://doi.org/10.1371/journal.pmed.1002522 29522519
Štítky
Interní lékařstvíČlánek vyšel v časopise
PLOS Medicine
2019 Číslo 11
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