Clinical significance of cytochrome P450 genetic polymorphism – Part I. Enzymatic system of cytochrome P450 and cytochrome P450 1A2
Authors:
Jana Ďuricová; Milan Grundmann
Authors place of work:
Ostravská Univerzita v Ostravě, Lékařská fakulta, Ústav klinické farmakologie FN
Published in the journal:
Čes. slov. Farm., 2011; 60, 110-115
Category:
Přehledy a odborná sdělení
Summary
Inter-individual variability in drug response is a major clinical problem. Much of the variability has been observed in drug metabolism, particularly in the enzymes of cytochrome P450. Genetic polymorphism in these enzymes may influence a patient’s response to commonly prescribed drugs. The first part of this review describes the enzymatic system of cytochrome P450 and further focuses on the influence of genetic polymorphism of cytochrome P450 1A2 on drug effect.
Key words:
cytochrome P450 – genetic polymorphism – CYP1A2
Zdroje
1. Gonzalez, F. J., Gelboin, H. V.: Human Cytochrome P450: Evolution and cDNA-directed expression. Environ. Health Perspect. 1992; 98, 81–85.
2. Omiecinski, C. J., Remmel, R. P., Hosagrahara, V.P.: Concise review of the cytochrome P450s and their roles in toxicology. Toxicol. Sci. 1999; 48, 151–156.
3. Chang, G. W., Kam, P. C.: The physiological and pharmacological roles of cytochrome P450 isoenzymes. Anaesthesia 1999; 54, 42–50.
4. Anzenbacher, P, Anzenbacherová, E.: Cytochromes P450 and metabolism of xenobiotics. Cell. Mol. Life. Sci. 2001; 58, 737–747.
5. Guengerich, F. P.: Cytochrome P450: What have we learned and what are the future issues? Drug. Metab. Rev. 2004; 36, 159–197.
6. Soucek, P., Gut, I.: Co je to cytochrom P 450? Enzymatické formy cytochromu P450 – dosažený stupeň znalostí. Cas. Lek. Cesk. 1993; 12, 353–358.
7. Guengerich, F. P.: Cytochromes P450, drugs and diseases. Mol. Interv. 2003; 3, 194–204.
8. Guengerich, F. P.: Cytochrome P450s and other enzymes in drug metabolism and toxicity. The APPS J. 2006; 8, E101–110.
9. Guengerich, F. P.: Update information on human P450s. Drug. Metab. Rev. 2002; 34, 7–15.
10. Güzey, C., Spigset, O.: Genotyping as a tool to predict adverse drug reactions. Curr. TP. Med. Chem. 2004; 4, 1411–1421.
11. Rogers, J. F., Nafzinger, A. N., Bertino, J. S.: Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450 – metabolized drugs. Am. J. Med. 2002; 113, 746–750.
12. Buzková, H., Pechandová, K., Slanař, O., Perlík, F.: Genetic polymorphism of cytochrome P450 and methods for its determination. Prague. Med. Rep. 2006; 107: 383–393.
13. Dahl, M. L.: Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics. Useful aid to Prescribing? Clin. Pharmacokinet. 2002; 41, 453–470.
14. Home page of the human cytochrome P450 (CYP 2D6) allele nomenclature (updated 2010 July 20). Available from: http://www.cypalleles.ki.se/cyp2d6.htm
15. Bertilsson, L.: Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. Clin. Pharmacokinet. 1995; 29, 192–209.
16. Ingelman-Sundberg, M.: Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends. Pharmacol. Sci. 2004; 25, 193–200.
17. Pirmohamed, M., Park, B. K.: Cytochrome P450 enzyme polymorphisms and adverse drug reactions. Toxicology 2003; 192, 23–32.
18. Steiner, E., Iselius, L., Alván, G., Lindsten, J., Sjöqvist, F.: A family study of genetic and environmental factors determing polymorphic hydroxylation of debrisoquin. Clin. Pharmacol. Ther. 1985; 38, 394–401.
19. Aklillu, E., Herrlin, K., Gustafsson, L. L., Bertilsson, L., Ingelman-Sundberg, M.: Evidence for environmental influence on CYP2D6-cataysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living or in Sweden. Pharmacogenetics 2002; 12, 375–383.
20. Wolbold, R., Klein, K., Burk, O., Nüssler, A. K., Neuhaus, P., Eichelbaum, M., Schwab, M., Zanger, U. M.: Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 2003; 38, 978–988.
21. Villeneuve, J. P., Pichette, V.: Cytochrome P450 and liver diseases. Curr. Drug. Metab. 2004; 5, 273–282.
22. Tracy, T. S., Venkataramanan, R., Glover, D., Caritis, S. N.: Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A4 activity) during pregnancy. Am J Obstet. Gynecol. 2005; 192, 633–639.
23. Schaffer, S. D., Yoon, S., Zadezensky, I.: A review of smoking cessation: potentially risky effects on prescribed medications. J. Clin. Nurs. 2009; 18, 1533–1540.
24. Nekvidová, J., Anzenbacher, P.: Interactions of food and dietary supplements with drug metabolising cytochrome P450 enzymes. Ces slov. Farm. 2007; 56, 165–173.
25. Guengerich, F. P.: Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Am. J. Clin. Nutr. 1995; 61, 651–658.
26. Tanaka E., Hisawa S.: Clinically significant pharmacokinetic drug interactions with psychoactive drugs: antidepressants and antipsychotics and the cytochrome P450 system. J. Clin. Pharm. Ther. 1999; 24, 7–16.
27. Perucca, E.: Clinically relevant drug interactions with antiepileptic drugs. Br. J. Clin. Pharmacol. 2005; 61, 246–255.
28. Jain, K. K.: Applications of AmpliChip CYP450. Mol. Diagn. 2005; 9, 119–127.
29. Pucci, L., Geppetti, A., Maggini, V., Lucchesi, D., Maria Rossi A., Longo V.: CYP1A2 F21L and F186L polymorphisms in an Italian population sample. Drug Metab. Pharmacokinet. 2007; 22, 220–222.
30. Ghotbi, R., Christensen, M., Roh, H., Ingelman-Sundberg M., Aklillu E, Bertilsson L.: Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur. J. Clin. Pharmacol. 2007; 63, 537–546.
31. Sachse, C., Brockmöller, J., Bauer, S., Roots, I.: Functional signifance of a C→A polymorphism in intron I of the cytochrome P450 CYP1A2 gene tested with caffeine. Br. J. Clin. Pharmacol. 1999; 47, 445–449.
32. Nakajima, M., Yokoi, T., Mizutani, M., Kinoshita, M., Funayama, M., Kamataki, T.: Genetic polymorphism in the 5’-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans. J. Biochem. 1999;125, 803–808.
33. Aklillu, E., Carrillo, J. A., Makonnen, E., Hellman K., Pitarque M., Bertilsson L., Ingelman-Sundberg M.: Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1. Mol. Pharmacol. 2003; 64, 659–69.
34. Relling, M. V., Lin, J. S., Ayers, G. D., Evans, W. E.: Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A activities. Clin. Pharmacol. Ther. 1992; 52, 643–658.
35. Zhou, S. F., Yang, L. P., Zhou, Z. W., Liu, Y. H., Chan, E.: Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. AAPS J. 2009; 11: 481–494.
36. Uslu, A., Ogus, C., Ozdemir, T., Bilgen, T., Tosun, O., Keser, I.: The effect of CYP1A2 gene polymorphism on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients. BMB Rep. 2010; 43, 530–534.
37. Obase, Y, Shimoda, T, Kawano, T, Saeki, S., Tomari, S. Y., Mitsuta-Izaki, K., Matsuse, H., Kinoshita, M., Kohno, S.: Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with astma. Clin. Pharmacol. Ther. 2003; 73, 468–474.
38. Eap, C. B., Bender, .S, Jaquenoud Sirot, E., Cucchia, G., Jonzier-Perey, M., Baumann, P., Allorge, D., Broly, F.: Nonresponse to clozapine and ultrarapid CYP1A2 activity: Clinical data and analysis of CYP1A2 gene. J. Clin. Psychopharmacol. 2004; 24, 214–219.
39. Ozdemir, V., Kalow, W., Okey, A. B., Lam, M. S., Albers, L. J., Reist, C., Fourie, J., Posner, P., Collins, E. J., Roy, R.: Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C→A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine. J. Clin. Psychopharmacol. 2001; 21, 603–606.
40. Bondolfi G., Morel F., Crettol S., Rachid F., Baumann P., Eap C. B.: Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients. Ther. Drug. Monit. 2005; 27, 539–543.
41. Jaquenoud Sirot, E., Knezevic, B., Morena, G. P., Harenberg, S., Oneda, B., Crettol, S., Ansermot, N., Baumann, P., Eap, C. B.: ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine. J. Clin. Psychopharmacol. 2009; 29, 319–326.
42. Kootstra-Ros, J. E., Smallegoor, W., van der Weide, J.: The cytochrome P450 CYP1A2 genetic polymorphisms *1F and *1D do not affect clozapine clearance in a group of schizophrenic patients. Ann. Clin. Biochem. 2005; 42, 216–219.
43. Laika, B., Leucht, S., Heres, S., Schneider, H., Steimer, W.: Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome. Pharmacogenomics J. 2010; 10, 20–29.
44. Shirley, K. L., Hon, Y. Y., Penzak, S. R., Lam, Y. W., Spratlin, V., Jann, M. W.: Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteers. Neuropsychopharmacology 2003; 28, 961–966.
45. Bohanec Grabar, P., Rozman, B., Tomsic, M., Suput, D., Logar, D., Dolzan, V.: Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. Eur. J. Clin. Pharmacol. 2008; 64, 871–876.
46. Fuhr, U., Rost, K. L.: Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva. Pharmacogenetics 1994; 4, 109–116.
47. Palatini, P., Ceolotto, G., Ragazzo, F., Dorigatti, F., Saladini, F., Papparella, I., Mos, L., Zanata, G., Santonastaso, M.: CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J. Hypertens. 2009; 27, 1594–1601.
48. Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., Campos, H.: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA 2006; 295, 1135–1141.
Štítky
Farmacie FarmakologieČlánek vyšel v časopise
Česká a slovenská farmacie
![Číslo 3](https://www.prolekarniky.cz/media/cache/resolve/journal_issue/media/image_pdf/f15019b0ae5ccca8770d8601206ead20.jpeg)
2011 Číslo 3
- AI místo lékaře? Výzkum zkoumal ochotu Čechů konzultovat své zdraví s umělou inteligencí
- Ze života konopného pacienta
- Příznivý vliv Armolipidu Plus na hladinu cholesterolu a zánětlivé parametry u pacientů s chronickým subklinickým zánětem
- Berberin: přírodní hypolipidemikum se slibnými výsledky
Nejčtenější v tomto čísle
- Význam genetického polymorfizmu enzýmov cytochrómu P450 – časť I.Enzýmový systém cytochrómu P450 a cytochróm P450 1A2
- doc. RNDr. Eva Račanská, CSc. – laureátka Weberovej ceny SFS
- Vplyv membrán na permeáciu alaptidu z hydrogélov
- Farmaceutické aspekty živočíšnej lipoxygenázy